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Checking in on body issues - Fatness and Baldness.. On the topic of the challenge of keeping weight off after reduction - published in the journal Nature: Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity1,2. However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes3,4. Overcoming this barrier for long-term treatment success is difficult because the molecular mechanisms underpinning this phenomenon remain largely unknown. Here, by using single-nucleus RNA sequencing, we show that both human and mouse adipose tissues retain cellular transcriptional changes after appreciable weight loss. Furthermore, we find persistent obesity-induced alterations in the epigenome of mouse adipocytes that negatively affect their function and response to metabolic stimuli. Mice carrying this obesogenic memory show accelerated rebound weight gain, and the epigenetic memory can explain future transcriptional deregulation in adipocytes in response to further high-fat diet feeding. In summary, our findings indicate the existence of an obesogenic memory, largely on the basis of stable epigenetic changes, in mouse adipocytes and probably other cell types. These changes seem to prime cells for pathological responses in an obesogenic environment, contributing to the problematic ‘yo-yo’ effect often seen with dieting. Targeting these changes in the future could improve long-term weight management and health outcomes.
All you Slenders out there - do you fucking understand that?
The body seems to retain an obesogenic memory that defends against body weight changes. So - people yo-yo'ing their body mass is not, as you all would have us believe - a failure of will power / moral fiber / lack of understanding about the perils of obesity.. It is a result of the body fighting weight changes at a MOLECULAR LEVEL. You fucking self-righteous twits... That's why every day for me is a motherfucking struggle to not overeat.. Every motherfucking day.. Humiliating. Humbling. Enraging.. Exhausting.. "Amid photos of balding scalps and eager gossip about new remedies on a Reddit thread about hair loss, you’ll often find cries of distress.
“I don’t feel at peace, ever. My nervous system is constantly in fight or flight,” read one in response to a question last year about the “absolute worst part about balding.”
The site, on which all of the pictured scalps are male, highlights an age-old phenomenon. While women may also lose hair, men do so in greater numbers, earlier and, on average, more obviously.
What’s different today, say experts, is that male anguish about it has never been more evident. Social media, dating apps, “Zoom dysphoria” and a sometimes-predatory marketplace are stoking the anxiety.
“I’m seeing more of a visible mental breakdown all over social media,” says Spencer Kobren, founder of the American Hair Loss Association, a national nonprofit dedicated to educating the public about “the emotionally devastating disease of hair loss.” “These are desperate, angry guys." I'm a long time baldy. At the age of 14, I was told by my barber that I would lose my hair.. Sure enough, he was right. By the time I was in my late 40's I had lost enough so that I just said "FuckIt" and shaved the whole dome. I never looked back. I never felt "Insecure" or "Emotionally devastated" by the "disease" of baldness. Maybe because I'm a Bood. Maybe it's because I've turned my back on all the judgement I've received over my lifetime about my appearance.. Hair too long, beard too long, clothes too shabby etc... that baldness was just one more thing. Fuck em all but six... I feel deep compassion for men who struggle with baldness. It breaks my heart to see people spend so much dough and emotional energy over something so benign as hair falling out.. ~
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